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Showing 1 - 3 of 3 matches in All Departments
Gap junctions between glial cells or neurons are ubiquitously
expressed in the mammalian brain and play a role in brain
development including cell differentiation, cell migration and
survival, and tissue homeostasis, as well as in human diseases
including hearing loss, neuropathies, epilepsy, brain trauma, and
cardiovascular disease. This volume provides neuroscience
researchers and students with a single source for information
covering the physiological, behavioral and pathophysiological roles
of gap junctions in the brain. In addition, the book also discusses
human disease conditions associated with mutations in single gap
junction connexion genes, making it applicable to clinicians doing
translational research. Finally, it includes reviews of
pharmacological studies with gap junction blockers and openers,
summarizing information obtained from phenotyping gap junctions
mouse mutants. Serves as the most current and comprehensive reference available covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease conditions associated with mutations in single gap junction connexin genes. Includes reviews of pharmacological studies with gap junction blockers and openers, summarizing information obtained from phenotyping gap junctions mouse mutants.
Episodic memory is the name of the kind of memory that records
personal experiences instead of the mere remembering of impersonal
facts and rules. This type of memory is extremely sensitive to
ageing and disease so an understanding of the mechanisms of
episodic memory might lead to the development of therapies suited
to improve memory in some patient populations. Episodic memory is
unique in that it includes an aspect of self-awareness and helps us
to remember who we are in terms of what we did and what we have
been passed through and what we should do in the future.
Human health issues relating to amino acids are extremely broad and include metabolic disorders of amino acid metabolism as well as their presence in food and use as supplements. This book covers the biochemistry of amino acid metabolism in the context of health and disease. It discusses their use as food supplements, in clinical therapy and nutritional support and focuses on major recent developments, highlighting new areas of research that will be needed to sustain further interest in the field.
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